Selected publications & applications

We have a wide range of peer reviewed publications based on our unique know how and software tools that hold ideas that can be valuable for your projects or business. We have experience in advanced multivariate analytics with Artificial Intelligence as core engines of the analysis. We have done and continue to service our partners in the food, chemical, agriculture, energy, pharmaceutical, materials and environmental sciences. Our proprietary InSight software has been a powerful tool in simplifying how we undertake analytics. CONTACT US for further information.

Application examples:

  1. Odour and sensory classification of consumer products
  2. Fast automated analysis and identification of over 1000 peaks in a GC-MS analysis of biomass combustion
  3. Monitoring transdermal drug delivery process by ATR-FTIR spectroscopy with Focal plane array detection
  4. Automated detection of biomarkers in saliva pre and post exercise with Chromatography coupled with Mass Spectrometer (LC-MS)
  5. Monitoring combustion gases of various materials by Infrared Spectroscopy (FTIR)
  6. Polymerization reaction monitoring by Infrared Spectroscopy
  7. Polymerization reaction monitoring by Near Infrared Spectroscopy (NIR)
  8. Starch & Iodine reaction monitoring by Raman Spectroscopy
  9. Polymerization reaction monitoring by Raman Spectroscopy
  10. Stack gas monitoring by FTIR
  11. Thermogravimetric-Infrared (TG-FTIR) analysis of biological materials
  12. Automated detection of metabolites in pathological urine samples by Capillary Electrophoresis and UV spectrometry.
  13. Analysis of race horse urine samples for doping metabolites by HPLC and Electrophoresis
  14. Optimization of a Capillary Electrophoresis system by multivariate spectral tracking
  15. Optimization of an HPLC system by multivariate spectral tracking
  16. Detection and Classification of Cancer Cells by FTIR spectroscopy
  17. Use of Quantitative Structure Activity Relationships (QSAR) for predictions of Auto-ignition Temperatures using Artificial Intelligence (AI)
  18. Use of Quantitative Structure Activity Relationships (QSAR) for predictions of Flash Points, Boiling points, Critical temperatures using Artificial Intelligence (AI)

List of publications:

  1. McAdam, K. G., Tetteh, J., Bishop, L., Digard, H., Cote, J., Lubbe, S., & Liu, C. (2020). A combined Study of Headspace Volatiles using Human Sensory, Mass Spectrometry and chemometrics. Scientific reports10(1), 1-17.
  2. Davies, A., Nicol, J. T. G., Liu, C., Tetteh, J., & McAdam, K. (2018). Identification of volatiles from heated tobacco biomass using direct thermogravimetric analysis—Mass spectrometry and target factor analysis. Thermochimica Acta668, 132-141.
  3. Boateng, J. S., Pawar, H. V., & Tetteh, J. (2015). Evaluation of in vitro wound adhesion characteristics of composite film and wafer based dressings using texture analysis and FTIR spectroscopy: A chemometrics factor analysis approach. RSC advances5(129), 107064-107075.
  4. Pawar, Harshavardhan V., Boateng, Joshua S., Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi: 10.1002/jps.23968 )
  5. Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2013) An integrated buccal delivery system combining chitosan films impregnated with peptide loaded PEG-b-PLA nanoparticles. Colloids and Surfaces B: Biointerfaces, 112. pp. 9-15. ISSN 0927-7765 (doi: 10.1016/j.colsurfb.2013.07.019 )
  6. Asare-Addo, Kofi, Conway, Barbara R., Larhrib, Hassan, Levina, Marina, Rajabi-Siahboomi, Ali R., Tetteh, John, Boateng, Joshua and Nokhodchi, Ali (2013) The effect of pH and ionic strength of dissolution media on in-vitro release of two model drugs of different solubilities from HPMC matrices. Colloids and Surfaces B: Biointerfaces, 111. pp. 384-391. ISSN 0927-7765 (doi: 10.1016/j.colsurfb.2013.06.034 )
  7. Pawar, H.V., Tetteh, J. and Boateng, J.S. (2013) Preparation and characterization of novel wound healing film dressings loaded with streptomycin and diclofenac. Colloids and Surfaces B: Biointerfaces, 102. pp. 102-110. ISSN 0927-7765 (doi: 10.1016/j.colsurfb.2012.08.014 )
  8. McAuley, W. J., Chavda-Sitaram, S., Mader, K. T., Tetteh, J., Lane, M. E., & Hadgraft, J. (2013). The effects of esterified solvents on the diffusion of a model compound across human skin: An ATR-FTIR spectroscopic study. International journal of pharmaceutics447(1-2), 1-6.
  9. Boateng, Joshua S., Pawar, Harshavardhan V. and Tetteh, John (2013) Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing. International Journal of Pharmaceutics, 441 (1-2). pp. 181-191. ISSN 0378-5173 (doi: 10.1016/j.ijpharm.2012.11.045 )
  10. Barontini, F., Tugnoli, A., Cozzani, V., Tetteh, J., Jarriault, M., & Zinovik, I. (2013). Volatile products formed in the thermal decomposition of a tobacco substrate. Industrial & Engineering Chemistry Research52(42), 14984-14997.
  11. Zand, Nazanin, Chowdhry, Babur Z., Pullen, Frank S., Snowden, Martin J. and Tetteh, John (2012) Simultaneous determination of riboflavin and pyridoxine by UHPLC/LC–MS in UK commercial infant meal food products. Food Chemistry, 135 (4). pp. 2743-2749. ISSN 0308-8146 (doi: 10.1016/j.foodchem.2012.07.064 )
  12. Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2012) Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): A potential approach for buccal delivery of macromolecules. International Journal of Pharmaceutics, 428 (1-2). pp. 143-151. ISSN 0378-5173 (doi: 10.1016/j.ijpharm.2012.02.035 )
  13. Pawar, H.V., Tetteh, J. and Boateng, J. (2012) Preparation and evaluation of streptomycin and diclofenac loaded mucoadhesive films for wound healing. Wound Repair and Regeneration, 20 (2). A34. ISSN 1067-1927 (Print), 1524-475X (Online) (doi: 10.1111/j.1524-475X.2012.00774.x )
  14. Tortoe, C., Orchard, J., Beezer, A. and Tetteh, J. (2011) Application of radial basis function network with a Gaussian function of artificial neural networks in osmo-dehydration of plant materials. Journal of Artificial Intelligence, 4 (4). pp. 233-244. ISSN 1994-5450 (Print), 2077-2173 (Online) (doi: 10.3923/jai.2011.233.244 )
  15. McAuley, W.J., Lad, M.D., Mader, K.T., Santos, P., Tetteh, J., Kazarian, S.G., Hadgraft, J. and Lane, M.E. (2010) ATR-FTIR spectroscopy and spectroscopic imaging of solvent and permeant diffusion across model membranes. European Journal of Pharmaceutics and Biopharmaceutics, 74 (2). pp. 413-419. ISSN 0939-6411 (doi: 10.1016/j.ejpb.2009.11.004 )
  16. Zand, Nazanin, Zotor, Francis B., Chowdhry, Babur, Tetteh, John, Wray, Dave and Amuna, Paul (2010) Determination of mineral content of commercial infant foods in the United Kingdom. Proceedings of the Nutrition Society, 69 (OCE6). ISSN 0029-6651 (doi: 10.1017/S0029665110003484 )
  17. McAuley, William J., Mader, Kerstin T., Tetteh, John, Lane, Majella E. and Hadgraft, Jonathan (2009) Simultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopy. European Journal of Pharmaceutical Sciences, 38 (4). 378- 383. ISSN 0928-0987 (doi: 10.1016/j.ejps.2009.09.002 )
  18. Zotor, F.B., Amuna, P., Tetteh, J. and Ndanu, T. (2009) Age and gender influences on sensory perceptions of novel low cost nutrient-rich food products developed using traditional Ghanaian food ingredients. Annals of Nutrition & Metabolism, 54 (3). pp. 247-248. ISSN 0250-6807 (doi: 10.1159/000226431 )
  19. Russeau, Wanessa, Mitchell, John, Tetteh, John, Lane, Majella E. and Hadgraft, Jonathan (2009) Investigation of the permeation of model formulations and a commercial ibuprofen formulation in Carbosil® and human skin using ATR-FTIR and multivariate spectral analysis. International Journal of Pharmaceutics, 374 (1-2). pp. 17-25. ISSN 0378-5173 (doi: 10.1016/j.ijpharm.2009.02.018 )
  20. Tetteh, J., Mader, K.T., Andanson, J.-M., McAuley, W.J., Lane, M.E., Hadgraft, J., Kazarian, S.G. and Mitchell, J.C. (2009) Local examination of skin diffusion using FTIR spectroscopic imaging and multivariate target factor analysis. Analytica Chimica Acta, 642 (1-2). pp. 246-256. ISSN 0003-2670 (doi: 10.1016/j.aca.2009.03.002 )
  21. Tortoe, Charles, Orchard, John, Beezer, Anthony and Tetteh, John (2008) Artificial neural networks in modelling osmotic dehydration of foods. Journal of Food Processing and Preservation, 32 (2). pp. 270-285. ISSN 1745-4549 (online) (doi: 10.1111/j.1745-4549.2008.00178.x )
  22. O’Neill, M. A., Beezer, A. E., Tetteh, J., Gaisford, S., & Dhuna, M. (2007). Application of chemometric analysis to complexity in isothermal calorimetric data. The Journal of Physical Chemistry B111(28), 8145-8149.
  23. Snell, C., Tetteh, J., & Evans, I. H. (2005). Phylogeography of the pool frog (Rana lessonae Camerano) in Europe: evidence for native status in Great Britain and for an unusual postglacial colonization route. Biological journal of the Linnean Society85(1), 41-51.
  24. Dias, M., Hadgraft, J., Raghavan, S. L., & Tetteh, J. (2004). The effect of solvent on permeant diffusion through membranes studied using ATR‐FTIR and chemometric data analysis. Journal of pharmaceutical sciences93(1), 186-196.
  25. Chowdhry, B. Z., Mendham, A. P., Tetteh, J., & Withnall, R. (2002). Kinetic Resonance Raman Spectroscopy of the Briggs–Rauscher Oscillator. ChemPhysChem3(5), 443-446.
  26. Metcalfe, E., & Tetteh, J. (2000). Combustion Toxicity and Chemometrics.
  27. Jackson, Michael, Keith Kim, John Tetteh, James R. Mansfield, Brion Dolenko, Raymond L. Somorjai, F. William Orr, Peter H. Watson, and Henry H. Mantsch. (1998, April). Cancer diagnosis by infrared spectroscopy: methodological aspects. In Infrared spectroscopy: new tool in medicine (Vol. 3257, pp. 24-34). International Society for Optics and Photonics.
  28. Tetteh, J., Metcalfe, E., Howells, S., Withnall, R., Ames, S., & Vollam, S. (1996). Orthogonal noise annihilation for FTIR spectroscopy in fire gas analysis. Fire and materials20(1), 51-59.